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Foot-and-mouth disease. Acantholysis in a sample of a skin vesicle. Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).

Acantholysis is the loss of intercellular connections resulting in loss of cohesion between keratinocytes[1], seen in diseases such as pemphigus vulgaris.[2]

This histological feature is also seen in herpes simplex infections (HSV 1 and 2).

See also


  1. ^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0721601871.
  2. ^ Medical Dictionary Entry


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