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Aceclofenac: Wikis

  

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Aceclofenac
Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Identifiers
CAS number 89796-99-6
ATC code M01AB16 M02AA25
PubChem 71771
Chemical data
Formula C 16H13Cl2NO4  
Mol. mass 354.18472 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status POM (UK)
Routes oral, topical

Aceclofenac is a non-steroidal anti-inflammatory drug. It is manufactured by Intas Biopharmaceuticals, under the tradename Hifenac in various forms (tablets, gel, injection etc.). Another trade name is Acetal.

It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100mg twice daily. It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

References

  • British National Formulary 55, March 2008; ISBN 978 085369 776 3 p.537

it have higher antiinflammatory action more than the conventional NSAIDS

cytokine inhibitor Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation








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