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Acral Acanthosis Nigricans also known as Acral Acanthotic Anomaly (AAA) - Acral acanthosis nigricans is a common and thus important variant of Acanthosis nigricans.[1][2][3] Classical acanthosis nigricans is characterized by hyperpigmented, velvety thickening of the skin typically on the nape and sides of the neck and in the axillae and groin [4]. It is also known as acral acanthotic anomaly, the two terms being synonymous. The former emphasizes that it is a type of acanthosis nigricans, the latter its uniqueness. It was discovered by internationally renowned dermatologist Robert A. Schwartz. Its original description in 1981 observed it as a disorder seen relatively commonly as velvety hyperpigmented plaques in dark complexioned individuals. It is often particularly prominent over the elbows, knees, knuckles and dorsal surfaces of the feet in otherwise healthy individuals with axillae and other intertriginous regions appearing normal[5].



The etiology of acral acanthosis nigricans is unknown. Its presence does not suggest the necessary of an evaluation for the presence of internal malignancy[5].

See also


  1. ^ Schwartz RA (February 2007). "Acral acanthosis nigricans (acral acanthotic anomaly)". J. Am. Acad. Dermatol. 56 (2): 349–50. doi:10.1016/j.jaad.2006.09.027. PMID 17224380.  
  2. ^ Schwartz RA (September 1981). "Acral acanthotic anomaly (AAA)". J. Am. Acad. Dermatol. 5 (3): 345–6. PMID 7263979.  
  3. ^ Schwartz RA (July 1994). "Acanthosis nigricans". J. Am. Acad. Dermatol. 31 (1): 1–19; quiz 20–2. PMID 8021347.  
  4. ^ Sinha S, Schwartz RA (September 2007). "Juvenile acanthosis nigricans". J. Am. Acad. Dermatol. 57 (3): 502–8. doi:10.1016/j.jaad.2006.08.016. PMID 17592743.  
  5. ^ a b Tilgen W (2009). "Benign epidermal tumors". in WHC Burgdorf, G Plewig, HH Wolff, M Landthaler, O Braun-Falco. Braun-Falco's Dermatology (3rd ed.). Heidelberg: Springer. pp. 1340–7. ISBN 3540293124.  

Further reading

  • Sidhom C, El Euch D, Hammami S, Zargouni A, Mokni M, Ben Osman Dhahri A (December 2004). "[Acral acanthosis nigricans paraneoplastic: about one case]" (in French). Tunis Med 82 (12): 1121–3. PMID 15822516.  


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