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Acute myeloblastic leukemia with maturation: Wikis

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Acute myeloblastic leukemia with maturation
Classification and external resources

Myeloblast
ICD-O: M9874/3
MeSH D015470

M2 is a subtype of AML (Acute Myeloid Leukemia).

It is also known as "Acute Myeloblastic Leukemia with Maturation". [1]

Contents

Cause

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.

See also

References

  1. ^ "Acute Myeloid Leukemia - Signs and Symptoms". http://www.ucsfhealth.org/adult/medical_services/cancer/leukemia/conditions/aml/signs.html.  
  2. ^ Taj AS, Ross FM, Vickers M, et al. (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890–2. PMID 7772527.  

External links

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