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Adenovirus serotype 36: Wikis

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Adenovirus serotype 36
Virus classification
Group: Group I (dsDNA)
Family: Adenoviridae
Genus: Mastadenovirus
Species: Human adenovirus D (HAdV-D)

Human adenovirus 36 (HAdV-36) or AD-36 is one of 52 types of adenoviruses known to infect humans. AD-36 was first isolated in 1978 from the feces of a girl suffering from diabetes and enteritis,[1] and has long been recognized as a cause of respiratory and eye infections in humans.[2] It was first shown to be associated with obesity in chickens by Dr. Nikhil Dhurandhar.[3][4]

There has been a positive correlation between body fat and the presence of AD-36 antibodies in the blood [5]. Previous research showed that chicken or mice injected with similar types of viruses show a statistically significant weight gain.[3]

To date, AD-36 is the only human adenovirus that has been linked with human obesity, present in 30% of obese humans and 11% of nonobese humans.[6] In addition, a study of obese Americans indicates that about 30% of the obese individuals and only 5% of non-obese individuals have antibodies to Ad-36.[7] AD-36 also causes obesity in chickens, mice, rats, and monkeys.[6]

AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue.[8]

Contents

Public awareness

On March 18, 2006 the research of Richard Atkinson (University of Wisconsin) was posted on some websites. In those studies, blood tests conducted on over 2000 Australians showed that more than 20% of the study participants had contracted Ad-36 viral infection.

On January 26, 2009, many popular internet news portals ran reports of the pending release of scientific research by Professor Nikhil Dhurandhar (Pennington Biomedical Research Centre, Louisiana) implicating AD-36 as a potential cause for Britain's relatively high rate of adult obesity.[9]

See also

References

  1. ^ http://www.ncbi.nlm.nih.gov/pubmed/17425944?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Infectobesity: obesity of infectious origin
  2. ^ http://www.sciencedaily.com/releases/2007/08/070820103224.htm Common virus may contribute to obesity in some people
  3. ^ a b Dhurandhar, N V; B A Israel, J M Kolesar, G F Mayhew, M E Cook, R L Atkinson (2000). "Increased adiposity in animals due to a human virus". International Journal of Obesity 24: 989–996. doi:10.1038/sj.ijo.0801319.  
  4. ^ Whigham, Leah D.; Barbara A. Israel, and Richard L. Atkinson (2006). "Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals". Am J Physiol Regul Integr Comp Physiol 290: R190–R194.  
  5. ^ Augustus A.S., Atkinson R.L.; Dhurandhar N.V., Allison D.B., Bowen R.L., Israel B.A., Albu J.B. (2005). "Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids.". International Journal of Obesity 29: 281–286. PMID 15611785.  
  6. ^ a b Atkinson RL (2007). "Viruses as an etiology of obesity". Mayo Clin. Proc. 82 (10): 1192–8. PMID 17908526.  
  7. ^ http://www.ncbi.nlm.nih.gov/pubmed/10951537 Increased adiposity in animals due to a human virus
  8. ^ Rogers PM, Fusinski KA, Rathod MA, et al. (2007). "Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene". Int J Obes (Lond) 32: 397. doi:10.1038/sj.ijo.0803748. PMID 17984979.  
  9. ^ "Obesity Bug You Can Catch", Daily Express, 26 January 2009
    "Obesity Caught Like Common Cold", LiveScience, 26 January 2009

External links

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