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Adhyperforin: Wikis


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Systematic (IUPAC) name
dicyclohexylammonium; (1R,5S,6R,7S)-6-methyl-5-(2-methylbutanoyl)-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-2,9-dioxo-bicyclo[3.3.1]non-3-en-4-olate
CAS number 143183-63-5
ATC code none
PubChem 44427224
ChemSpider 23287670
Chemical data
Formula C18H77NO4 
Mol. mass 732.13 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Over-the-counter
Routes Oral

Adhyperforin is a phytochemical found in the members of the plant genus Hypericum including St. John's Wort.[1] It has a very similar pharmacological profile to hyperforin and acts as a TRPC6 ion channel activator,[1] thereby inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate.[1] Adhyperforin is found in St. John's Wort in levels approximately 1/10th those of hyperforin.[1]

See Also


  1. ^ a b c d Jensen AG, Hansen SH, Nielsen EO. (2001). "Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity.". Life Sci. 68 (14): 1593–1605. PMID 11263672. 


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