The Full Wiki

More info on Adinazolam

Adinazolam: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Adinazolam
Systematic (IUPAC) name
1-(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,5-a]
[1,4]benzodiazepin-1-yl)-N,N-dimethylmethanamine
Identifiers
CAS number 37115-32-5
ATC code N05BA07
PubChem 37632
DrugBank APRD00724
ChemSpider 34519
Chemical data
Formula C 19H18ClN5  
Mol. mass 351.8
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life < 3 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV(US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Adinazolam (marketed under the brand name Deracyn) is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant[1] properties. Adinazolam was developed by Dr. Jackson B. Hester, who was seeking to enhance the antidepressant properties of alprazolam, which he also developed.[2]

Contents

Indications

Adinazolam is indicated as a treatment for anxiety and status epilepticus.

Pharmacology

Adinazolam produces inhibitory effects by binding to GABA receptors. This increases the effects of GABA.

Metabolism

Adinazolam was reported to have active metabolites in the August 1984 issue of The Journal of Pharmacy and Pharmacology.[3] The main metabolite is N-desmethyladinazolam.[4] The other two metabolites are alpha-hydroxyalprazolam and estazolam.[5] In the August 1986 issue of that same journal, Sethy, Francis and Day reported that proadifen inhibited the formation of N-desmethyladinazolam.[6]

See also

References

  1. ^ Lahti, Robert A.; Vimala H. Sethy, Craig Barsuhn, Jackson B. Hester (November 1983). "Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine.". Neuropharmacology 22 (11): 1277–82. doi:10.1016/0028-3908(83)90200-9. PMID 6320036.  
  2. ^ "Discovers Award 2004" (PDF). Special Publications. Pharmaceutical Research and Manufactureres of America. April 2004. pp. 39. http://international.phrma.org/publications/publications//admin/2004-10-12.1086.pdf. Retrieved August 18, 2006.  
  3. ^ Sethy, Vimala H.; R. J. Collins and E. G. Daniels (August 1984). "Determination of biological activity of adinazolam and its metabolites.". Journal of Pharmacy and Pharmacology 36 (8): 546–8. PMID 6148400.  
  4. ^ Peng, G. W. (August 1984). "Assay of adinazolam in plasma by liquid chromatography.". Journal of Pharmaceutical Sciences 73 (8): 1173–5. doi:10.1002/jps.2600730840. PMID 6491930.  
  5. ^ Fraser, A. D.; A. F. Isner and W. Bryan (November-December 1993). "Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC.". Journal of Analytical Toxicology 17 (7): 427–31. PMID 8309217.  
  6. ^ Sethy, Vimala H.; Jonathan W. Francis and J. S. Day (August 1986). "The effect of proadifen on the metabolism of adinazolam.". Journal of Pharmacy and Pharmacology 38 (8): 631–2. PMID 2876087.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message