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Afelimomab: Wikis

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Afelimomab ?
Monoclonal antibody
Source Mouse
Target TNFα
Identifiers
CAS number 156227-98-4
ATC code L04AB03
PubChem  ?
Chemical data
Formula  ?
Mol. mass  ?
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Afelimomab (MAK 195F) is an anti-TNFα monoclonal antibody. Administration of afelimomab reduces the concentration of interleukin-6 in patients with sepsis, but reduces mortality only marginally.[1][2]

References

  1. ^ Rondon, E.; Venkataraman, R. (2005). "Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels". Critical Care 9 (5): E20. doi:10.1186/cc3798. PMID 16277704.   edit
  2. ^ Panacek; Marshall, JC; Albertson, TE; Johnson, DH; Johnson, S; MacArthur, RD; Miller, M; Barchuk, WT et al. (2004). "Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels". Critical care medicine 32 (11): 2173–82. PMID 15640628.   edit
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