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Afloqualone
Systematic (IUPAC) name
6-amino- 2-(fluoromethyl)- 3-(2-methylphenyl) quinazolin- 4-one
Identifiers
CAS number 56287-74-2
ATC code none
PubChem 2040
ChemSpider 1960
Chemical data
Formula C 16H14FN3O 
Mol. mass 283.3
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Afloqualone (Arofuto) is an analogue of methaqualone developed in the 1980s in Japan. It has sedative and muscle relaxant effects,[1] and has had some clinical use, although it causes photosensitization as a side effect which can cause skin problems such as dermatitis.[2]

See also

References

  1. ^ Ochiai T, Ishida R. Pharmacological studies on 6-amino- 2-fluoromethyl- 3-(O-tolyl)- 4(3H)- quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Japanese Journal of Pharmacology. 1982 Jun;32(3):427-38.
  2. ^ Ishikawa T, Kamide R, Niimura M. Photoleukomelanodermatitis (Kobori) induced by afloqualone. Journal of Dermatology. 1994 Jun;21(6):430-3.
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