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Alanine racemase: Wikis

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alanine racemase
Identifiers
EC number 5.1.1.1
CAS number 9024-06-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology AmiGO / EGO

In enzymology, an alanine racemase (EC 5.1.1.1) is an enzyme that catalyzes the chemical reaction

L-alanine \rightleftharpoons D-alanine

Hence, this enzyme has one substrate, L-alanine, and one product, D-alanine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is alanine racemase. This enzyme is also called L-alanine racemase. This enzyme participates in alanine and aspartate metabolism and D-alanine metabolism. It employs one cofactor, pyridoxal phosphate. At least one compound, 3-Fluoro-D-alanine is known to inhibit this enzyme.

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1BD0, 1EPV, 1FTX, 1L6F, 1L6G, 1NIU, 1RCQ, 1SFT, 1VFH, 1VFS, 1VFT, 1XFC, 1XQK, 1XQL, 2DY3, and 2SFP.

References

  • MARR AG, WILSON PW (1954). "The alanine racemase of Brucella abortus". Arch. Biochem. Biophys. 49: 424–33. PMID 13159289.  
  • Wood WA (1955). "Amino acid racemases". Methods Enzymol. 2: 212–217. doi:10.1016/S0076-6879(55)02189-7.  
  • WOOD WA, GUNSALUS IC (1951). "D-Alanine formation; a racemase in Streptococcus faecalis". J. Biol. Chem. 190: 403–16. PMID 14841188.  

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