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Alazocine: Wikis

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Alazocine
Identifiers
CAS number 14198-28-8
PubChem 3036246
SMILES
Properties
Molecular formula C17H23NO
Molar mass 257.37 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Alazocine (SKF-10047), or N-allylnormetazocine , was the first drug discovered to act as a sigma receptor agonist.[1][2] It also acts as a κ-Opioid agonist, among other effects. Alazocine is related to pentazocine, ketazocine, phenazocine and the other benzomorphans (which are all κ-Opioid agonists with varying affinity), and like it's relatives can and most likely will, especially if the dosage increases, cause precipitated withdrawal in those dependent on a full μ Opioid receptor (MOR) agonist i.e.: diacetylmorphine (heroin), fentanyl, meperidine, etc. (due to the benzomorphans having MOR antagonism, in addition to their MOR agonism). Full κ-Opioid receptor agonists have shown to also antagonize or rival the MOR to a degree.

References

  1. ^ Iwamoto ET. Pharmacologic effects of N-allylnormetazocine (SKF-10047). NIDA Research Monographs. 1981 Feb;34:82-8. PMID 6783955
  2. ^ Shearman GT, Herz A. Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat. European Journal of Pharmacology. 1982 Aug 27;82(3-4):167-72. PMID 6290235

Pentazocine

Dextromethorphan Noscapine Salvinorin A

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