The Full Wiki

Alclometasone: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
CAS number 66734-13-2
ATC code D07AB10 S01BA10
PubChem 5311000
DrugBank APRD00783
ChemSpider 4470541
Chemical data
Formula C 28H37ClO7  
Mol. mass 521.042 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Rx Only (US)
Routes topical

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.



Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).


Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.


  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

Side effects

Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

  • burning
  • itching
  • erythema
  • skin reddening
  • xerodermia
  • skin irritation
  • acne
  • hypopigmentation
  • prickly heat
  • folliculitis
  • white atrophy
  • hypertrichosis
  • reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%

External links



Got something to say? Make a comment.
Your name
Your email address