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Aldicarb
Skeletal formula of aldicarb
Ball-and-stick model of aldicarb
IUPAC name
Identifiers
CAS number 116-06-3 Yes check.svgY
PubChem 9570071
SMILES
InChI
InChI key QGLZXHRNAYXIBU-WEVVVXLNBS
ChemSpider ID 7844539
Properties
Molecular formula C7H14N2O2S
Molar mass 190.27 g/mol
Density 1.195 g/cm³
Melting point

100 °C, 373 K, 212 °F

Boiling point

Decomposes before boiling point

 Yes check.svgY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Aldicarb is a carbamate insecticide with structural formula: 2-methyl-2-(methylthio)propanal O-(N-methylcarbamoyl)oxime. Aldicarb is the active substance in Temik pesticide, which is effective against thrips, aphids, spider mites, lygus, fleahoppers, and leafminers but is primarily used as a nematicide.[1] Aldicarb is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse. In case of severe poisoning, the victim dies of respiratory failure.

Regulatory status

Aldicarb is approved by the USEPA for use by professional pesticide applicators on a variety of crops, including cotton, beans, and others. It is not approved for household use.[2]

"Tres Pasitos", a mouse, rat, and roach killer that contains high concentrations of aldicarb, has been illegally imported into the United States from Mexico and other Latin American countries. The product is highly toxic to animals and people, and according to the EPA "should never be used in [the] home."[3]

Toxicity in mammals

Aldicarb is a fast-acting cholinesterase inhibitor, causing rapid accumulation of acetylcholine at the synaptic cleft. It is widely used to study cholinergic neurotransmission in simple systems such as the nematode C. elegans.

Exposure to high amounts of aldicarb can cause weakness, blurred vision, headache, nausea, tearing, sweating, and tremors in humans. Very high doses can be fatal to humans because it can paralyze the respiratory system.[3]

It has a LD50 of 0.5 - 1.5 mg/kg when in liquid form and a LD50 of 7 mg/kg when in solid form.

References

  1. ^ "Temik". Bayer CropScience. http://www.bayercropscienceus.com/products_and_seeds/insecticides/temik.html. Retrieved 2008-01-11.  
  2. ^ "Aldicarb". Pesticide Information Profiles. The Extension Toxicology Network. June 1996. http://extoxnet.orst.edu/pips/aldicarb.htm. Retrieved 2007-08-13.  
  3. ^ a b EPA Illegal Pesticide Products, US Environmental Protection Agency
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