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Alexander Rich, MD (American; born 1924) is a biologist and biophysicist. He is the William Thompson Sedgwick Professor of Biophysics at MIT (since 1958) and Harvard Medical School. Dr. Rich earned both an A.B. (magna cum laude) and an M.D. (cum laude) from Harvard University. He was a post-doc of Linus Pauling along with James Watson. He has over 600 publications to his name.

Rich is the founder of Alkermes and has been its director since 1987. Dr. Rich is Co-Chairman of the Board of Directors of Repligen Corporation, a biopharmaceutical company. He is also a member of the Board of Directors for Profectus BioSciences, Inc. He also serves on the editorial board of Genomics and the Journal of Biomolecular Structure and Dynamics.

In 1963, Rich discovered polysomes: clusters of ribosomes which read one strand of mRNA simultaneously.[1]

In 1979, Rich and co-workers at MIT accidentally grew a crystal of Z-DNA.[2] This was the first crystal structure of any form of DNA. After 26 years of attempts, Rich et al. finally crystallised the junction box of B- and Z-DNA. Their results were published in an October 2005 Nature journal.[3] Whenever Z-DNA forms, there must be two junction boxes that allow the flip back to the canonical B-form of DNA.

Contents

List of awards and prizes received

References

  1. ^ Warner JR, Knopf PM, Rich A (1963). "A multiple ribosomal structure in protein synthesis". Proc. Natl. Acad. Sci. USA 49: 122–129. doi:10.1073/pnas.49.1.122. PMID 13998950. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=13998950.  
  2. ^ Wang AHJ, Quigley GJ, Kolpak FJ, Crawford JL, van Boom JH, Van der Marel G, and Rich A (1979). "Molecular structure of a left-handed double helical DNA fragment at atomic resolution". Nature 282 (5740): 680–686. doi:10.1038/282680a0. PMID 514347.  
  3. ^ Ha SC, Lowenhaupt K, Rich A, Kim YG, and Kim KK (2005). "Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases". Nature 437 (7062): 1183–1186. doi:10.1038/nature04088. PMID 16237447.  
  4. ^ "2008 Welch Award in Chemistry Recipient". The Welch Foundation. http://www.welch1.org/Awards/WelchAwardinChemist0943/CurrentRecipient.asp.  
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Selected publications

  • Brown BA II, Lowenhaupt K, Wilbert CM, Hanlon EB, Rich A (2000). "The Za domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA". Proc Nat'l Acad Sci USA 97:13531-13586.
  • Kim Y-G, Lowenhaupt K, Maas S, Herbert A, Schwartz T, Rich A (2000). "The Zab domain of the human RNA editing enzyme ADAR1 recognizes Z-DNA when surrounded by B-DNA". J Biol Chem 275:26828-26833.
  • Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A (1999). "Crystal structure of the Za domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA". Science 284:1841-1845.

External links


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