Alexis Carrel: Wikis

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Alexis Carrel

Born June 28, 1873
Sainte-Foy-lès-Lyon, Rhône, France
Died November 5, 1944 (aged 71)
Profession Surgeon, Biologist
Institutions University of Chicago
Rockefeller Institute for Medical Research.
Specialism transplantology, thoracic surgery
Known for New techniques in vascular sutures and pioneering work in transplantology and thoracic surgery.
Notable prizes Nobel Prize in Physiology or Medicine(1912)

Alexis Carrel (June 28, 1873 – November 5, 1944) was a French surgeon, biologist and eugenicist, who was awarded the Nobel Prize in Physiology or Medicine in 1912.

Contents

Biography

Born in Sainte-Foy-lès-Lyon , Rhône, Carrel received his medical degree from Université de Lyon, and practiced in France and in the United States at the University of Chicago and the Rockefeller Institute for Medical Research. He developed new techniques in vascular sutures and was a pioneer in transplantology and thoracic surgery. Alexis Carrel was also a member of learned societies in the U.S., Spain, Russia, Sweden, the Netherlands, Belgium, France, Vatican City, Germany, Italy and Greece and received honorary doctorates from Queen's University of Belfast, Princeton University, California, New York, Brown University and Columbia University. He collaborated with American physician Charles Claude Guthrie in work on vascular suture and the transplantation of blood vessels and organs as well as the head, and Carrel was awarded the 1912 Nobel Prize in Physiology or Medicine for these efforts.[1] Due to his close proximity with Jacques Doriot's fascist Parti Populaire Français (PPF) during the 1930s and his role in implementing eugenics policies during Vichy France, he was accused after the Liberation of collaborationism, but died before the trial.

Contributions to science

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Wound Antisepsis

During World War I (1914-1918), Carrel and the English chemist Henry Drysdale Dakin developed the Carrel-Dakin method of treating wounds based on chlorine (Dakin's solution) which, preceding the development of antibiotics, was a major medical advance in the care of traumatic wounds. For this, Carrel was awarded the Légion d'honneur.

Organ transplants

Carrel co-authored a book with famed pilot Charles A. Lindbergh, The Culture of Organs, and worked with Lindbergh in the mid-1930s to create the "perfusion pump," which allowed living organs to exist outside of the body during surgery. The advance is said to have been a crucial step in the development of open-heart surgery and organ transplants, and to have laid the groundwork for the artificial heart, which became a reality decades later.[2] Some critics of Lindbergh claimed that Carrel overstated Lindbergh's role to gain media attention,[3] but other sources say Lindbergh played an important role in developing the device.[4][5] Both Lindbergh and Carrel appeared on the cover of Time magazine on June 13, 1938.

Cellular senescence

Carrel was also interested in the phenomenon of senescence, or aging. He claimed that all cells continued to grow indefinitely, and this became a dominant view in the early twentieth century.[6] Carrel was especially famous for an experiment[7] begun on January 17, 1912. To defend his idea, Carrel placed tissue cultured from an embryonic chicken heart in a stoppered Pyrex flask of his own design, and maintained the living culture for over 20 years with regular supplies of nutrient. This was longer than a chicken's normal lifespan. The experiment, which was conducted at the Rockefeller Institute for Medical Research, attracted considerable popular and scientific attention.

Carrel's famous experiment was never fully replicated (although other researchers obtained mutated "immortal" strains), and in the 1960s research by Leonard Hayflick and Paul Moorhead proposed that earlier researchers were wrong, and that differentiated cells can only undergo a limited number of divisions before dying. This is known as the Hayflick limit, and is now a pillar of biology.[6]

It is not certain how Carrel obtained his anomalous results. Leonard Hayflick suggests that the daily feeding of nutrient was continually introducing new living cells to the alleged immortal culture.[8] J. A. Witkowski has argued that,[9] while "immortal" strains of visibly mutated cells have been obtained by other experimenters, a more likely explanation is deliberate introduction of new cells into the culture, possibly without Carrel's knowledge.[10]

Honors

In 1972, the Swedish Post Office honored Carrel with a stamp that was part of its Nobel stamp series.[11] In 1979, the lunar crater Carrel was named after him as a tribute to his scientific breakthroughs.

In February 2002 the Medical University of South Carolina at Charleston, within the celebrations for the Lindbergh 100th birthday established the Lindbergh-Carrel Prize,[12] given to major contributors to "development of perfusion and bioreactor technologies for organ preservation and growth". M. E. DeBakey and 9 other scientists[13] received the prize, a bronze statuette espressly created for the event by the Italian artist C. Zoli and named "Elisabeth"[14] after Elisabeth Morrow, sister of Lindbergh's wife Anne Morrow, died due to heart disease. Lindbergh in fact was disappointed that contemporary medical technology could not provide an artificial heart pump which would allow for heart surgery on her and that gave the occasion for the first contact between Carrel and Lindbergh.

Man, The Unknown (1935)

In 1935, Carrel published a best-selling book titled L'Homme, cet inconnu (Man, The Unknown) which advocated, in part, that mankind could better itself by following the guidance of an elite group of intellectuals, and by implementing a regime of enforced eugenics. Carrel claimed the existence of a "hereditary biological aristocracy" and argued that "deviant" human types should be suppressed using techniques similar to those later employed by the Nazis.

"A euthanasia establishment, equipped with a suitable gas, would allow the humanitarian and economic disposal of those who have killed, committed armed robbery, kidnapped children, robbed the poor or seriously betrayed public confidence," Carrel wrote in L'Homme, cet Inconnu. "Would the same system not be appropriate for lunatics who have committed criminal acts?" he suggested.

In the 1936 preface to the German edition of his book, Alexis Carrel added a praise to the eugenics policies of the Third Reich, writing that:

(t)he German government has taken energetic measures against the propagation of the defective, the mentally diseased, and the criminal. The ideal solution would be the suppression of each of these individuals as soon as he has proven himself to be dangerous.[15]

Carrel also wrote in his book that:

(t)he conditioning of petty criminals with the whip, or some more scientific procedure, followed by a short stay in hospital, would probably suffice to insure order. Those who have murdered, robbed while armed with automatic pistol or machine gun, kidnapped children, despoiled the poor of their savings, misled the public in important matters, should be humanely and economically disposed of in small euthanasic institutions supplied with proper gasses. A similar treatment could be advantageously applied to the insane, guilty of criminal acts.[16]

The French Foundation for the Study of Human Problems

In 1937, Carrel joined Jean Coutrot’s Centre d’Etudes des Problèmes Humains - Coutrot’s aim was to develop what he called an "economic humanism" through "collective thinking." In 1941, through connections to the cabinet of Vichy France president Philippe Pétain (specifically, French industrial physicians André Gros and Jacques Ménétrier) he went on to advocate for the creation of the Fondation Française pour l’Etude des Problèmes Humains (French Foundation for the Study of Human Problems) which was created by decree of the Vichy regime in 1941, and where he served as 'regent'.[17]

The Foundation was behind the origin of the December 16, 1942 Act inventing the "prenuptial certificate", which had to precede any marriage and was supposed, after a biological examination, to insure the "good health" of the spouses, in particular in regard to sexually transmitted diseases (STD) and "life hygiene" (sic). Carrel's institute also conceived the "scholar book" ("livret scolaire"), which could be used to record students' grades in the French secondary schools, and thus classify and select them according to scholastic performance.

The foundation was at the origin of the October 11, 1946 law, enacted by the Provisional Government of the French Republic (GPRF), which institutionalized the field of occupational medicine. It worked on demographics (Robert Gessain, Paul Vincent, Jean Bourgeois-Pichat), on economics, (François Perroux), on nutrition (Jean Sutter), on habitation (Jean Merlet) and on the first opinion polls (Jean Stoetzel). "The foundation was chartered as a public institution under the joint supervision of the ministries of finance and public health. It was given financial autonomy and a budget of forty million francs—roughly one franc per inhabitant—a true luxury considering the burdens imposed by the German Occupation on the nation’s resources. By way of comparison, the whole Centre National de la Recherche Scientifique (CNRS) was given a budget of fifty million francs."[18]

According to Gwen Terrenoire, writing in Eugenics in France (1913-1941) : a review of research findings, "The foundation was a pluridisciplinary centre that employed around 300 researchers (mainly statisticians, psychologists, physicians) from the summer of 1942 to the end of the autumn of 1944. After the liberation of Paris, Carrel was suspended by the Minister of Health; he died in November 1944, but the Foundation itself was "purged", only to reappear in a short time as the Institut national d’études démographiques (INED) that is still active."[19] Although Carrel himself died on November 5, 1944, most members of his team did move to the INED, which was led by famous demographist Alfred Sauvy, who coined the expression "Third World". Others joined Robert Debré's "Institut national d'hygiène" (National Hygiene Institute), which later became the INSERM.

Alexis Carrel and Lourdes

Alexis Carrel went from being a skeptic of the visions and miracles reported at Lourdes to being a believer after experiencing a healing he could not explain.[20] To the detriment of his career and reputation among his fellow doctors, he steadfastly reiterated his beliefs,[20] and even wrote a book describing his experience.[21]

See also

External links

Sources

  • Carrel, Alexis. Man, The Unknown. New York and London: Harper and Brothers. 1935.
  • Feuerwerker, Elie. Alexis Carrel et l'eugénisme. Le Monde, 1er Juillet 1986.
  • Andrés Horacio Reggiani. Alexis Carrel, the Unknown: Eugenics and Population Research under Vichy (FRENCH HISTORICAL STUDIES 25:2 SPRING 2002)[22]
  • Wallace, Max. The American Axis: Henry Ford, Charles Lindbergh, and the Rise of the Third Reich St. Martin's Press, New York, 2003.
  • Szasz, Thomas. The Theology of Medicine New York: Syracuse University Press, 1977.
  • Ali, Tariq. Clash of Fundamentalisms Verso, London, 2002
  • Choueiri, Youssef. Islamic Fundamentalism Continuum International Publishing Group, London, 2002.
  • Walther, Rudolph. Die seltsamen Lehren des Doktor Carrel, DIE ZEIT 31.07.2003 Nr.32[23]
  • Bonnafé, Lucien and Tort, Patrick. L'Homme, cet inconnu? Alexis Carrel, Jean-Marie le Pen et les chambres a gaz Editions Syllepse, 1996.[24] ISBN 2907993143
  • Abu-Rabi, Ibrahim M. Intellectual Origins of Islamic Resurgence, SUNY Press, Albany, 1996
  • Azmeh, Aziz (Aziz Al-Azmeh). Islams and Modernities Verso, London, 1993.
  • Berman, Paul. Terror and Liberalism W. W. Norton, 2003
  • David Zane Mairowitz. "Fascism à la mode: in France, the far right presses for national purity", Harper's Magazine; 10/1/1997
  • Pioneers of Islamic Revival (edited by Ali Rahnema), Zed Books, London 1994
  • Schneider, William. Quality and Quantity: The Quest for Biological Regeneration in Twentieth-Century France, Cambridge Studies in the History of Medicine (chap. 7 French eugenics in the thirties; and 10 Vichy and after)
  • Terrenoire, Gwen, CNRS. Eugenics in France (1913-1941) : a review of research findings Joint Programmatic Commission UNESCO-ONG Science and Ethics, March 24, 2003[25]

References

  1. ^ Nobelprize.org
  2. ^ Red Gold . Innovators & Pioneers . Alexis Carrel | PBS
  3. ^ (Wallace, American Axis p. 101)
  4. ^ The Doric Column - Lindbergh & Carrel, organ perfusion, tissue culture, transplants, gene therapy
  5. ^ The "Lone Eagle's" Contribution to Cardiology
  6. ^ a b Fossel, Michael B. (2004). Cells, Aging, and Human Disease. Oxford University Press. http://books.google.com/books?id=UYeUk9m9yeQC&pg=PA24&sig=UQYSI7zRB8WYtkV-2yosc6GK28w.  ; page 24.
  7. ^ Carrel, Alexis (1912-05-01). "On the Permanent Life of Tissues Outside of the Organism" (PDF). Journal of Experimental Medicine 15 (5): 516–528. doi:10.1084/jem.15.5.516. PMID 19867545. PMC 2124948. http://jem.rupress.org/cgi/reprint/15/5/516.pdf. Retrieved 2009-05-28.  
  8. ^ Hayflick, L. (November 1997). "Mortality and Immortality at the Cellular Level. A Review". Biochemistry (Mosc) 62 (11): 1180–1190. PMID 9467840.  
  9. ^ Witkowski, JA (1980). "Dr. Carrel's immortal cells". Medical History 24 (2): 129–142. PMID 6990125. PMC 1082700. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1082700.  
  10. ^ Witkowsky explanation is actually based on the account of a visiting medical researcher, Ralph Buchbaum, who reports being told by a technician in Carrel's lab "Dr. Carrel would be so upset if we lost the strain, we just add a few embryo cells now and then". After the first six months, Carrel's colleague Albert Ebeling had actually taken charge of the cultures and published several papers about their development, until they were eventually discarded in 1946. Witkowsky, in "Dr. Carrel's immortal cells", op. cit., quotes Buchbaum's account. At the end Buchbaum writes that "I told this story, of my visit to Carrel's laboratory, to various people. Dr. Bloom (Buchbaum's director of research in Chicago)refused to believe it. Others chuckled gleefully. Dr. Carrel was to blame only in that he did not keep on top of what was really going on in the laboratory (mostly, he wrote the papers). Dr. Parker and Dr. Ebeling probably suspected something, hence the "retirement". In the interest of truth and science, the incident should have been thoroughly investigated. If it had been, some heads might have rolled, sacrificed to devotion to a wrong hypothesis - immortality of cell strains.". Witkowsky also reports a Dr. Margaret Murray telling him that "one of Carrel's technicians of that time was passionately anti-fascist and detested Carrel's political and social ideas" and expressing her belief that "that this technician would willingly have discredited Carrel scientifically if possible.".
  11. ^ The Nobel Stamps of 1972
  12. ^ Charles Lindbergh Symposium
  13. ^ Charles Lindbergh Symposium
  14. ^ Foundation Alexis Carrel for thoracic and cardiovascular researches
  15. ^ Quoted in Andrés Horacio Reggiani. Alexis Carrel, the Unknown: Eugenics and Population Research under Vichy (French historical studies, 25:2 Spring 2002) [1], p. 339. Also quoted in French by Didier Daeninckx in Quand le négationnisme s’invite à l’université., on Amnistia.net website, [2], URL consulted on January 28, 2007
  16. ^ Quoted in Szasz, Thomas. The Theology of Medicine New York: Syracuse University Press, 1977.
  17. ^ (see Andrés Horacio Reggiani, Alexis Carrel, the Unknown: Eugenics and Population Research under Vichy, as well as Caillois, p. 107)
  18. ^ (Reggiani) [3]
  19. ^ Gwen Terrenoire, "Eugenics in France (1913-1941): a review of research findings", Joint Programmatic Commission UNESCO-ONG Science and Ethics, 2003) [4]
  20. ^ a b Rev. Stanley Jaki Two Lourdes Miracles and a Nobel Laureate: What Really Happened?
  21. ^ Alexis Carrel, The Voyage to Lourdes (New York, Harper & Row, 1939).
  22. ^ French Historical Studies - Sign In Page
  23. ^ Die seltsamen Lehren des Doktor Carrel: Wie ein katholischer Arzt aus Frankreich zum Vordenker der radikalen Islamisten wurde | Nachrichten auf ZEIT ONLINE
  24. ^ Amazon.fr: L'Homme cet inconnu ? Alexis Carrel, Jean-Marie Le Pen et les Chambres à gaz: Lucien Bonnafé, Patrick Tort: Livres
  25. ^ Comité de Liaison ONG-UNESCO

Quotes

Up to date as of January 14, 2010

From Wikiquote

All great men are gifted with intuition. They know without reasoning or analysis, what they need to know.

Alexis Carrel (28 June 18735 November 1944) was a French surgeon and biologist. He was awarded the Nobel Prize in Physiology or Medicine in 1912.

Contents

Sourced

  • All great men are gifted with intuition. They know without reasoning or analysis, what they need to know.
    • As quoted in Nava-Vēda : God and Man (Nara and Narayan) (1968‎) by M. B. Raja Rao, p. 229

Attributed

  • To accomplish our destiny it is not enough merely to guard prudently against road accidents. We must also cover before nightfall the distance assigned to each of us.
  • Those who do not know how to fight worry die young.

Quotes about Carrel

  • An ordinary man can in a day's time travel by train from a dead little town of empty squares, where the sun, the dust, and the wind amuse themselves in silence, to a great capital city bristling with lights, gestures, and street cries. By reading a newspaper the inhabitant of a mountain village can tremble each day with anxiety, following insurrection in China, the London and New York suffragettes, Doctor Carrel, and the heroic dog-sleds of the polar explorers. The timid, sedentary inhabitant of any provincial town can indulge in the intoxication of danger by going to the movies and watching a great hunt in the Congo…

External links

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1911 encyclopedia

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Simple English

Alexis Carrel
File:Alexis Carrel
Alexis Carrel
BornJune 28, 1873
Lyons, France
DiedNovember 5, 1944
Paris, France
NationalityFrench
FieldSurgery
InstitutionsRockefeller Institute for Medical Research, New York, NY, USA
Alma materUniversity of Lyons
Known forTransplants
Notable prizesNobel Prize in Physiology or Medicine (1912)

Alexis Carrel (June 28, 1873 - November 5, 1944) was a French surgeon.[1] He won the 1912 Nobel Prize in Physiology or Medicine, for his work on joining blood vessels and the transplantation of blood vessels and organs.[2]

References


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