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From Wikipedia, the free encyclopedia

Alloimmunity is a condition in which the body gains immunity, from another individual of the same species, against its own cells.[1]

Alloimmunity should not be confused with autoimmunity in which the body's immune system attacks its own cells without being provoked or influenced by substances or cells from another member of the same species.

One alloantigen is known as "Qa-1".[2]

If either alloimmunity or autoimmunity is directed against red blood cells (RBCs), the direct Coombs test is positive.



An alloantigen is an antigen that is a part of an animal's self-recognition system. e.g., Major histocompatibility complex molecules. When injected into another animal, they trigger an immune response aimed at eliminating them. Therefore, it can be thought of as an antigen that is present in some members of the same species, but is not common to all members of that species. If an alloantigen is presented to a member of the same species that does not have the alloantigen, it will be recognized as foreign. They are the products of polymorphic genes.[3]


Alloimmunity can occur

Alloimmunity can be regulated by neonatal B cells.[4]

See also


  1. ^ McCance, Kathryn L.; Huether, Sue E. (1996). Understanding pathophysiology. St. Louis, MO: Mosby-Year Book, Inc. pp. 185. ISBN 0-8151-4081-9.  
  2. ^ Germana S, Shinohara N (December 1991). "Qa-1/Tla region alloantigen-specific CTL with alpha beta receptor". Immunology 74 (4): 578–82. PMID 1838350.  
  3. ^ Abbas AK and Lichtman AH. Basic Immunology: Functions and Disorders of the Immune System. Second Edition, Updated Edition 2006-2007. Elsevier Saunders Publishing.
  4. ^ Walker WE, Goldstein DR (August 2007). "Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity". J. Immunol. 179 (3): 1700–10. PMID 17641036.  

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