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Allylglycine: Wikis

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Allylglycine
Allylglycine.png
IUPAC name
Identifiers
CAS number 7685-44-1
PubChem 14044
SMILES
Properties
Molecular formula C5H9NO2
Molar mass 115.13 g/mol
Melting point

265 °C, 538 K, 509 °F

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Allylglycine is a glycine derivative. It is an inhibitor of the enzyme glutamate decarboxylase.[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[2] It is used to induce convulsions in animals in scientific studies.

References

  1. ^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology 27 (11): 1171–7. PMID 3205383.  
  2. ^ Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford) 22 (6): 633–41. doi:10.1177/0269881107082902. PMID 18308797. http://jop.sagepub.com/cgi/pmidlookup?view=long&pmid=18308797.  
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