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Systematic (IUPAC) name
CAS number 143413-68-7
ATC code none
PubChem 178132
ChemSpider 8002134
Chemical data
Formula C 26H38N2O4  
Mol. mass 442.589 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Alnespirone (S-20499) is a psychoactive drug and research chemical from the azapirone chemical class that has anxiolytic and antidepressant properties. It acts as a high affinity 5-HT1A receptor full agonist.[1][2] Unlike some of the other azapirone derivatives such as buspirone, alnespirone is fully selective for the 5-HT1A receptor and has negligible affinity for the D2 or α2-adrenergic receptor.[1][2][3]


  1. ^ a b Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.". Neuroreport. 3 (1): 84–86. PMID 1351756.  
  2. ^ a b Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.". Psychopharmacology (Berl). 108 (1-2): 47–50. PMID 1357709.  
  3. ^ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.". Eur J Pharmacol. 459 (1): 17–26. PMID 12505530.  


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