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Alpha-2 blocker: Wikis


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Although alpha blocker generally refers to α1-blockers, there are also α2-blockers, which are antagonists to the α2 adrenergic receptor. They are mainly used in research, finding little clinical application in human medicine, although yohimbine was previously used as an aphrodisiac, and is still sometimes used in veterinary medicine (although now largely replaced by atipamezole) for reversing the effects of alpha-2 agonists such as medetomidine which are used as sedatives during surgery.

One area where alpha-2 blockers are medically useful is in treating depression; the tetracyclic antidepressants mianserin and mirtazapine are alpha-2 blockers, though their efficacy as antidepressants may come from their activity at other receptor sites.


Examples include atipamezole,[1] efaroxan, idazoxan,[2] yohimbine and rauwolscine.


  1. ^ Haapalinna A, Leino T, Heinonen E (November 2003). "The alpha 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats". Naunyn Schmiedebergs Arch. Pharmacol. 368 (5): 342–51. doi:10.1007/s00210-003-0827-z. PMID 14566451.  
  2. ^ Chopin P, Colpaert FC, Marien M (February 1999). "Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway". J. Pharmacol. Exp. Ther. 288 (2): 798–804. PMID 9918591.  


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