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Alpha-ethyltryptamine: Wikis

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Systematic (IUPAC) name
CAS number 2235-90-7
ATC code none
PubChem 8367
ChemSpider 8064
Chemical data
Formula C 12H16N2  
Mol. mass 188.27 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 222–223 °C (432–433 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule I (US)
Routes  ?

α-Ethyltryptamine (αET, AET; Monase), also known as etryptamine, is a psychedelic, stimulant, and entactogen of the tryptamine chemical class.


Originally believed to exert its effects predominantly via monoamine oxidase inhibition, αET was developed as an antidepressant by Upjohn Chemical Company in the United States under the name Monase, but was withdrawn from commercial use after a year due to the unacceptable occurrence of agranulocytosis. αET was abused as a designer drug in the 1980s, and was subsequently added to the United States Schedule I list of illegal substances in 1993.


αET is structurally and pharmacologically related to α-methyltryptamine (αMT), but its effects are slightly different. In contrast to αMT, αET is less stimulating and hallucinogenic, and its effects resemble more those of entactogens like MDMA ("Ecstasy"). Similarly to MDMA, αET has been demonstrated to be a serotonin, norepinephrine, and dopamine releasing agent in scientific research, with primary actions on the former neurotransmitter, as well as a serotonergic neurotoxin.[1] It also acts as a non-selective serotonin receptor agonist.

See also


  1. ^ Huang XM, Johnson MP, Nichols DE (July 1991). "Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase)". European Journal of Pharmacology 200 (1): 187–90. PMID 1722753.  

External links

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