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Alphamethylacetylfentanyl: Wikis

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Systematic (IUPAC) name
CAS number 101860-00-8
ATC code none
PubChem 62307
ChemSpider 56102
Chemical data
Formula C 22H28N2O 
Mol. mass 336.471 g/mol
SMILES eMolecules & PubChem
Synonyms α-methylacetylfentanyl, acetyl-α-methylfentanyl
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule I (CA) Class A (UK) Schedule I (US)
Routes  ?

α-methylacetylfentanyl is an opioid analgesic that is an analogue of fentanyl.

α-methylacetylfentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared. [1] α-methylacetylfentanyl is made with the same synthetic route as α-methylfentanyl, but by substituting the relatively common acetic anhydride for the more difficult to obtain chemical propionic anhydride in the synthesis.

α-methylacetylfentanyl has similar effects to fentanyl. Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression which can be life-threatenng.


  1. ^ Henderson GL. Designer Drugs: Past History and Future Prospects. Journal of Forensic Sciences 1988; 33(2):569-575

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