The Full Wiki

More info on Altinicline

Altinicline: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number 179120-92-4
ATC code  ?
PubChem 3036156
Chemical data
Formula C12H14N2 
Mol. mass 186.252
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Altinicline (SIB-1508Y) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype.[1][2] It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models,[3] and progressed as far as Phase II clinical trials for Parkinson's disease,[4] although its current status is unclear.


  1. ^ Cosford, ND; Bleicher; Vernier; Chavez-Noriega; Rao; Siegel; Suto; Washburn et al. (2000). "Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist". Pharmaceutica acta Helvetiae 74 (2-3): 125–30. doi:10.1016/S0031-6865(99)00024-2. PMID 10812948.  edit
  2. ^ Wagner, F.; Comins, D. (2006). "Expedient five-step synthesis of SIB-1508Y from natural nicotine". The Journal of organic chemistry 71 (22): 8673–8675. doi:10.1021/jo0616052. PMID 17064057.  edit
  3. ^ Rao, T.; Adams, P.; Correa, L.; Santori, E.; Sacaan, A.; Reid, R.; Cosford, N. (2008). "Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist". Brain research 1234: 16–24. doi:10.1016/j.brainres.2008.07.063. PMID 18692487.  edit
  4. ^ The Parkinson Study Group. Randomized placebo-controlled study of the nicotinic agonist SIB-1508Y in Parkinson disease. Neurology. 2006;66:408-410. doi:10.1212/01.wnl.0000196466.99381.5c


Got something to say? Make a comment.
Your name
Your email address