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Alvameline
Systematic (IUPAC) name
3-(2-Ethyltetrazol-5-yl)-1-methyl-5,6-dihydro-2H-pyridine
Identifiers
ATC code none
PubChem 178030
ChemSpider 154980
Chemical data
Formula C9H15N5 
Mol. mass 193.25 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled

Alvameline (Lu 25-109) is a M1 receptor agonist and M2/M3 receptor antagonist[1] that was under investigation for the treatment of Alzheimer's disease, but produced poor results in clinical trials[2] and was subsequently discontinued.

See also

References

  1. ^ Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J (June 1998). "In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro". Psychopharmacology 137 (3): 233–40. PMID 9683000. http://link.springer.de/link/service/journals/00213/bibs/8137003/81370233.htm. 
  2. ^ Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR (1998). "A bridging study of LU 25-109 in patients with probable Alzheimer's disease". Life Sciences 62 (3): 195–202. PMID 9488097. http://linkinghub.elsevier.com/retrieve/pii/S0024320597010874. 
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