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Ambenonium chloride
Systematic (IUPAC) name
2,2'-[(1,2-dioxoethane-1,2-diyl)diimino]bis[ N-(2-chlorobenzyl)-N,N-diethylethanaminium]
Identifiers
CAS number 7648-98-8
ATC code N07AA30
PubChem 8288
DrugBank APRD00771
ChemSpider 7987
Chemical data
Formula C 28H42Cl2N4O2 +2
Mol. mass 537.564 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability Low
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral
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Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor[1] used in the management of myasthenia gravis.

It is classified as reversible.[2]

Mechanism of Action

Ambenonium exerts its actions against Myasthenia Gravis by competitive reversible inhibition of acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine. Myasthenia Gravis occurs when the body produces antibodies against acetylcholine receptors, and thus inhibits signal transmission across the myoneural junction. Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. This, in turn, facilitates transmission of impulses across the myoneural junction and effectively treats the disease

Indications

Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).

References

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