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Systematic (IUPAC) name
CAS number 134-80-5
ATC code A08AA03
PubChem 7029
DrugBank 7029
ChemSpider 6762
Chemical data
Formula C13H19NO 
Mol. mass 205.30 g/mol
SMILES eMolecules & PubChem
Synonyms Diethylpropion
Therapeutic considerations
Pregnancy cat. B
Legal status Schedule IV (US)
Routes Oral

Amfepramone (INN, other names diethylcathinone and diethylpropion, trade names Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil, Tenuate), is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.



Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone.[1] Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively.[1] As a result, ethcathinone and amfepramone can essentially be considered selective norepinephrine releasing agents (NRAs).


Amfepramone has been found to be neurotoxic in that it causes long-term depletions of serotonin similarly to methamphetamine and MDMA ("Ecstasy").[2]


Amfepramone is classified as a Schedule IV controlled substance in the United States.

See also


  1. ^ a b Rothman RB, Baumann MH (2006). "Therapeutic potential of monoamine transporter substrates". Current Topics in Medicinal Chemistry 6 (17): 1845–59. PMID 17017961. 
  2. ^ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301


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