The Full Wiki

More info on Amfepramone

Amfepramone: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Amfepramone
Systematic (IUPAC) name
(RS)-2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number 134-80-5
ATC code A08AA03
PubChem 7029
DrugBank 7029
ChemSpider 6762
Chemical data
Formula C13H19NO 
Mol. mass 205.30 g/mol
SMILES eMolecules & PubChem
Synonyms Diethylpropion
Therapeutic considerations
Pregnancy cat. B
Legal status Schedule IV (US)
Routes Oral

Amfepramone (INN, other names diethylcathinone and diethylpropion, trade names Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil, Tenuate), is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.

Contents

Pharmacology

Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone.[1] Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively.[1] As a result, ethcathinone and amfepramone can essentially be considered selective norepinephrine releasing agents (NRAs).

Neurotoxicity

Amfepramone has been found to be neurotoxic in that it causes long-term depletions of serotonin similarly to methamphetamine and MDMA ("Ecstasy").[2]

Legality

Amfepramone is classified as a Schedule IV controlled substance in the United States.

See also

References

  1. ^ a b Rothman RB, Baumann MH (2006). "Therapeutic potential of monoamine transporter substrates". Current Topics in Medicinal Chemistry 6 (17): 1845–59. PMID 17017961. http://www.bentham-direct.org/pages/content.php?CTMC/2006/00000006/00000017/0004R.SGM. 
  2. ^ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message