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Amfonelic acid
Systematic (IUPAC) name
1-ethyl-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic acid
CAS number 15180-02-6
ATC code none
PubChem 2137
Chemical data
Formula C18H16N2O3 
Mol. mass 308.331 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled

Amfonelic acid (AFA; WIN-25978) is a psychoactive drug and research chemical used in scientific studies. It acts as a potent and highly selective dopamine reuptake inhibitor (DRI).[1][2] It has a moderately long half-life of approximately 12 hours.

See also


  1. ^ Fuller RW, Perry KW, Bymaster FP, Wong DT. (1978). "Comparative effects of pemoline, amfonelic acid and amphetamine on dopamine uptake and release in vitro and on brain 3,4-dihydroxyphenylacetic acid concentration in spiperone-treated rats.". J Pharm Pharmacol. 30 (3): 197–198. PMID 24701. 
  2. ^ McMillen BA, Shore PA. (1978). "Amfonelic acid, a non-amphetamine stimulant, has marked effects on brain dopamine metabolism but not noradrenaline metabolism: association with differences in neuronal storage systems.". J Pharm Pharmacol. 30 (7): 464–466. PMID 27622. 


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