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Amorolfine
Systematic (IUPAC) name
(2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
Identifiers
CAS number 78613-35-1
ATC code D01AE16
PubChem 54260
ChemSpider 49010
Chemical data
Formula C 21H35N 
Mol. mass 317.509 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Amorolfine (or amorolfin), is an allylamine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a nail lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status, but still requires a prescription in other countries such as Norway. It is also available without prescription in Australia.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.

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