Amoxapine: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Amoxapine
Systematic (IUPAC) name
2-Chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
Identifiers
CAS number 14028-44-5
ATC code N06AA17
PubChem 2170
DrugBank APRD00142
ChemSpider 2085
Chemical data
Formula C 17H16ClN3O 
Mol. mass 313.781
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (cytochrome P450 system)
Half life 8-10 hours (30 hours for major metabolites)
Excretion Renal
Therapeutic considerations
Pregnancy cat. C(US)
Legal status -only (US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Amoxapine (Asendin, Asendis, Defanyl, Demolox, Moxadil) is a tetracyclic antidepressant (TeCA) of the piperazine and dibenzoxazepine chemical classes.

Contents

Uses

It is used in the treatment of depression, anxiety disorders, panic disorder, and bipolar disorder.

It also has action similar to an atypical antipsychotic.[1]

Pharmacology

Amoxapine is a strong of norepinephrine reuptake inhibitor and weakserotonin reuptake inhibitor. It also posses antiadrenergic, anticholinergic, antidopaminergic, antihistamine, and antiserotonergic actions.

Side effects

One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome. Amoxapine is also associated with acute extrapyramidal symptoms and tardive dyskinesia.

See also

References

  1. ^ Apiquian R, Fresan A, Ulloa RE, et al. (December 2005). "Amoxapine as an atypical antipsychotic: a comparative study vs risperidone". Neuropsychopharmacology 30 (12): 2236–44. doi:10.1038/sj.npp.1300796. PMID 15956984. http://dx.doi.org/10.1038/sj.npp.1300796.  

Further reading

  • Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
  • Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
  • Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.







Got something to say? Make a comment.
Your name
Your email address
Message