The Full Wiki

More info on Ampicillin/sulbactam

Ampicillin/sulbactam: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Ampicillin/sulbactam
Combination of
Ampicillin Penicillin antibiotic
Sulbactam Beta-lactamase inhibitor
Identifiers
CAS number  ?
ATC code J01CR01
PubChem 656676
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ampicillin/sulbactam is a combination of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist. The first, developed in 1987 and marketed in the United States under the tradename Unasyn, is an intravenous antibiotic. The second, an oral form called sultamicillin, is marketed under the trade name Ampictam outside of the United States. Ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.

Ampicillin-2D-skeletal.png Sulbactam.svg Sultamicillin schematic.svg
Skeletal formula of ampicillin Skeletal formula of sulbactam Skeletal formula of sultamicillin, highlighting ampicillin in blue and sulbactam in orange

Ampicillin/sulbactam is also used when the cause of an infection is not known (empiric therapy). Intra-abdominal infections, skin infections, pneumonia, and gynecologic infections. It is active against a wide range of bacterial groups, including Staphylococcus aureus, Enterobacteriaceae, and anaerobic bacteria. Importantly, it is not active against Pseudomonas aeruginosa and should not be used alone when infection with this organism is suspected or known.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message