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Amrinone: Wikis

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Amrinone
Systematic (IUPAC) name
5-amino-3,4'-bipyridin-6(1H)-one
Identifiers
CAS number 60719-84-8
ATC code C01CE01
PubChem 3698
ChemSpider 3570
Chemical data
Formula C 10H9N3O 
Mol. mass 187.198 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability n/a
Protein binding 10 to 49%
Metabolism Hepatic
Half life 5 to 8 hours
Excretion Renal (63%) and fecal (18%)
Therapeutic considerations
Pregnancy cat. C(US)
Legal status -only (US)
Routes Intravenous
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Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone[1]), trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor.[2]

Contents

Uses

It is used in the treatment of congestive heart failure.

It has been studied for use before coronary artery bypass surgery.[3]

Actions

Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme.

Indications

Short-term management of severe CHF (not used long term because of increased mortality, probably due to heart failure)

Contraindications

Patients with history of hypersensitivity to the drug

Precautions

May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.

Side effects

Thrombocytopenia, hepatotoxicity, arrhythmia, nausea, & vomiting

Routes

IV bolus and infusion as described earlier

Pediatric dosage

Safety in children has not been established

References

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