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The Amsterdam criteria identify families likely to have Hereditary nonpolyposis colorectal cancer (HNPCC).^[1][2][3][4]

Critera

At least 3 relatives with an HNPCC-associated cancer: colorectal cancer, or cancer of the endometrium, small intestine, ureter or renal pelvis.

• The patient should be a first degree relative of the others

• Two successive generations should be affected with disease

• One tumour should be diagnosed before 50 years of age - including non colorectal cancers.

• Familial adenomatous polyposis should be excluded in the colorectal cancer case (if any is evident)

• Tumours should be verified by histopathologic examination

• Confirmatory genetic testing may be completed as indicated

Alternatives

Revisions include "Amsterdam criteria II" and "revised Bethesda guidelines".^[5]

References