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Angiotensin II receptor type 2: Wikis


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Angiotensin II receptor, type 2
Symbols AGTR2; AT2; ATGR2; MRX88
External IDs OMIM300034 MGI87966 HomoloGene20172 IUPHAR: AT2 GeneCards: AGTR2 Gene
RNA expression pattern
PBB GE AGTR2 207294 at tn.png
PBB GE AGTR2 207293 s at tn.png
PBB GE AGTR2 222321 at tn.png
More reference expression data
Species Human Mouse
Entrez 186 11609
Ensembl ENSG00000180772 ENSMUSG00000068122
UniProt P50052 Q3US12
RefSeq (mRNA) NM_000686 NM_007429
RefSeq (protein) NP_000677 NP_031455
Location (UCSC) Chr X:
115.22 - 115.22 Mb
Chr X:
20.64 - 20.65 Mb
PubMed search [1] [2]

Angiotensin II receptor type 2, also known as the AT2 receptor or AGTR2, is a human gene.[1]

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.[1]



Angiotensin II receptor type 2 has been shown to interact with MTUS1.[2]

See also


  1. ^ a b "Entrez Gene: AGTR2 angiotensin II receptor, type 2".  
  2. ^ Nouet, Sandrine; Amzallag Nathalie, Li Jian-Mei, Louis Simon, Seitz Isabell, Cui Tai-Xing, Alleaume Anne-Marie, Di Benedetto Mélanie, Boden Christine, Masson Maryline, Strosberg A Donny, Horiuchi Masatsugu, Couraud Pierre-Olivier, Nahmias Clara (Jul. 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". J. Biol. Chem. (United States) 279 (28): 28989–97. doi:10.1074/jbc.M403880200. ISSN 0021-9258. PMID 15123706.  

External links

Further reading

  • de Gasparo M, Catt KJ, Inagami T, "et al." (2000). "International union of pharmacology. XXIII. The angiotensin II receptors". Parmacol Rev. 52: 415–472. PMID 10977869.  
  • D'Amore A, Black MJ, Thomas WG (2005). "The angiotensin II type 2 receptor causes constituative growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy". Hypertension 46: 1347–1354. PMID 16286564.  
  • Regitz-Zagrosek V, Neuss M, Warnecke C, et al. (1997). "Subtype 2 and atypical angiotensin receptors in the human heart.". Basic Res. Cardiol. 91 Suppl 2: 73–7. PMID 8957548.  
  • Berry C, Touyz R, Dominiczak AF, et al. (2002). "Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.". Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400.  
  • Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.". Biochem. Biophys. Res. Commun. 183 (2): 910–6. doi:10.1016/0006-291X(92)90570-B. PMID 1550596.  
  • Hein L, Barsh GS, Pratt RE, et al. (1995). "Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.". Nature 377 (6551): 744–7. doi:10.1038/377744a0. PMID 7477266.  
  • Ichiki T, Labosky PA, Shiota C, et al. (1995). "Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.". Nature 377 (6551): 748–50. doi:10.1038/377748a0. PMID 7477267.  
  • Lazard D, Briend-Sutren MM, Villageois P, et al. (1995). "Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.". Recept. Channels 2 (4): 271–80. PMID 7719706.  
  • Martin MM, Elton TS (1995). "The sequence and genomic organization of the human type 2 angiotensin II receptor.". Biochem. Biophys. Res. Commun. 209 (2): 554–62. doi:10.1006/bbrc.1995.1537. PMID 7733925.  
  • Chassagne C, Beatty BG, Meloche S (1995). "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization.". Genomics 25 (2): 601–3. doi:10.1016/0888-7543(95)80072-T. PMID 7790004.  
  • Koike G, Horiuchi M, Yamada T, et al. (1994). "Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.". Biochem. Biophys. Res. Commun. 203 (3): 1842–50. doi:10.1006/bbrc.1994.2402. PMID 7945336.  
  • Martin MM, Su B, Elton TS (1995). "Molecular cloning of the human angiotensin II type 2 receptor cDNA.". Biochem. Biophys. Res. Commun. 205 (1): 645–51. doi:10.1006/bbrc.1994.2714. PMID 7999093.  
  • Tsuzuki S, Ichiki T, Nakakubo H, et al. (1994). "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.". Biochem. Biophys. Res. Commun. 200 (3): 1449–54. doi:10.1006/bbrc.1994.1613. PMID 8185599.  
  • Servant G, Boulay G, Bossé R, et al. (1993). "Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium.". Mol. Pharmacol. 43 (5): 677–83. PMID 8502225.  
  • Yamada T, Horiuchi M, Dzau VJ (1996). "Angiotensin II type 2 receptor mediates programmed cell death.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 156–60. doi:10.1073/pnas.93.1.156. PMID 8552595.  
  • Zhang J, Pratt RE (1996). "The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus.". J. Biol. Chem. 271 (25): 15026–33. doi:10.1074/jbc.271.25.15026. PMID 8663053.  
  • Katsuya T, Horiuchi M, Minami S, et al. (1997). "Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome.". Mol. Cell. Endocrinol. 127 (2): 221–8. doi:10.1016/S0303-7207(97)04011-2. PMID 9099917.  
  • Akishita M, Ito M, Lehtonen JY, et al. (1999). "Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.". J. Clin. Invest. 103 (1): 63–71. doi:10.1172/JCI5182. PMID 9884335.  
  • Lehtonen JY, Daviet L, Nahmias C, et al. (1999). "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.". Mol. Endocrinol. 13 (7): 1051–60. doi:10.1210/me.13.7.1051. PMID 10406457.  
  • Knowle D, Ahmed S, Pulakat L (2000). "Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family.". Regul. Pept. 87 (1-3): 73–82. doi:10.1016/S0167-0115(99)00111-1. PMID 10710290.  
  • Hansen JL, Servant G, Baranski TJ, et al. (2000). "Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation.". Circ. Res. 87 (9): 753–9. PMID 11055978.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

G protein-coupled receptors



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