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Aniracetam
Systematic (IUPAC) name
1-[(4-methoxybenzoyl)]- 2-pyrrolidinone
Identifiers
CAS number 72432-10-1
ATC code N06BX11
PubChem 2196
ChemSpider 2111
Chemical data
Formula C 12H13NO3  
Mol. mass 219.237 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 1 - 2.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Unscheduled (US)
Routes Oral

Aniracetam (Draganon, Sarpul, Ampamet) is a nootropic compound of the racetam family purported to be considerably more potent than piracetam. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. Sold in the US as a dietary supplement while used in Europe as a prescription drug.

Aniracetam is an ampakine class Nootropic.

Contents

Pharmacology

After a confirmed test of the anxiolytic efficacy in a mouse model, receptor antagonists haloperidol, mecamylamine, and ketanserin were applied. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D2/D3 dopamine, nicotinic acetylcholine, and 5-HT2A receptors[1].

Aniracetam has also been shown to selectively modulate the AMPA glutamate receptor[2] and was used as the parent compound to derive a class of drugs known as the ampakines which are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease and other neurodegenerative conditions.1

Despite the fat solubility of aniracetam its half-life is much shorter than common racetam analogs such as Piracetam.

Commonly used doses are 750-3,000 mg daily usually taken in 2-3 doses.

Side effects can include nausea and headache.

See also

External links

References

  1. ^ Nakamura K; Kurasawa M (May 2001). "Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism". Eur J Pharmacol. (Kanagawa, Japan). 420 (1): 33–43. doi:10.1016/S0014-2999(01)01005-6. PMID 11412837.  
  2. ^ Ito et al. J. Physiol. 1990; 424: 533-543.







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