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Sir Michael Anthony Epstein CBE, FRS (b. 18 May 1921) was one of the discoverers of the Epstein-Barr virus.

Epstein was educated at St. Paul's School (London) in London, Trinity College, Cambridge and Middlesex Hospital Medical School. Epstein was Professor of Pathology, 1968-85 (now Professor Emeritus), and Head of Department, 1968-82 at the University of Bristol. In 1979 he was elected a Fellow of the Royal Society of London and was its Vice-President from 1986 to 1991. He was awarded its Royal Medal in 1992. He was awarded the CBE in 1985 and knighted in 1991. Epstein was a Fellow of Wolfson College, Oxford from its conception until 2001, and an Honorary Fellow since 2001. In 2006, Epstein was awarded a D.Sc. from Bristol. He is a Distinguished Supporter of the British Humanist Association.

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