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Antiandrogen: Wikis

  

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An antiandrogen, or androgen antagonist, is any of a group of hormone receptor antagonist compounds that are capable of preventing or inhibiting the biologic effects of androgens,[1] male sex hormones, on normally responsive tissues in the body. Antiandrogens usually work by blocking the appropriate receptors, competing for binding sites on the cell's surface, obstructing the androgens' pathway.

Contents

Indications

Antiandrogens are often indicated to treat severe male sexual disorders, such as hypersexuality (excessive sexual desire) and sexual deviation, specifically paraphilias, as well as use as an antineoplastic agent and palliative, adjuvant or neoadjuvant hormonal therapy in prostate cancer.

Antiandrogens can also be used for treatment of benign prostatic hyperplasia (prostate enlargement), acne vulgaris, androgenetic alopecia (male pattern baldness), and hirsutism (excessive hairiness). They are also occasionally used as a male contraceptive agent, to purposefully prevent or counteract masculinisation in the case of transsexual women undergoing sex reassignment therapy, and to prevent the symptoms associated with reduced testosterone, such as hot flashes, following castration. They can also be used for the treatment of PCOS or polycystic ovarian syndrome.

The administration of antiandrogens in males can result in slowed or halted development or reversal of male secondary sex characteristics, reduced activity or function of the accessory male sex organs, and hyposexuality (diminished sexual desire or libido).

Sometimes as a part of a program for registered sex offenders recently released from prisons, the offender is administered antiandrogen drugs to reduce the likelihood of repeat offending by reducing sexual drive etc.

Examples

Currently available antiandrogen drugs (brand names, which may include other active ingredients, in parentheses) include:

See also

References








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