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From Wikipedia, the free encyclopedia

An antidote is a substance which can counteract a form of poisoning.[1] The term ultimately derives from the Greek αντιδιδοναι antididonai, "given against".

The antidotes for some particular toxins are manufactured by injecting the toxin into an animal in small doses and extracting the resulting antibodies from the host animals' blood. This results in an antivenom that can be used to counteract poison produced by certain species of snakes, spiders, and other venomous animals. A number of venoms lack a viable antivenom, and a bite or sting from an animal producing such a toxin often results in death. Some animal venoms, especially those produced by arthropods (e.g. certain spiders, scorpions, bees, etc.) are only potentially lethal when they provoke allergic reactions and induce anaphylactic shock; as such, there is no "antidote" for these venoms because it is not a form of poisoning, though anaphylactic shock can be treated (e.g., by the use of epinephrine).

Some other toxins have no known antidote. For example, the poison ricin, which is produced from the waste byproduct of castor oil manufacture, has no antidote, and as a result is often fatal if it enters the human body in sufficient quantities.


Mechanical approaches

Ingested poisons are frequently treated by the oral administration of activated charcoal, which absorbs the poison and flushes it from the digestive tract, thereby removing a large part of the toxin.

Poisons which are injected into the body (such as those from bites or stings from venomous animals) are usually treated by the use of a constriction band which limits the flow of lymph and/or blood to the area, thus slowing circulation of the poison around the body. This should not be confused with use of a tourniquet which cuts off blood flow completely - often leading to the loss of the limb.

List of antidotes

Agent Indication
Activated charcoal with sorbital used for many oral toxins
Atropine organophosphate and carbamate insecticides, some mushrooms
Beta Blocker theophylline
Calcium chloride calcium channel blockers, black widow spider bites
Calcium gluconate hydrofluoric acid
Chelators such as EDTA, dimercaprol (BAL), penicillamine, and 2,3-dimercaptosuccinic acid (DMSA, succimer) heavy metal poisoning
Cyanide antidote(amyl nitrite, sodium nitrite, or thiosulfate) cyanide poisoning
Cyproheptadine serotonin syndrome
Deferoxamine mesylate Iron poisoning
Digoxin Immune Fab antibody (Digibind and Digifab) digoxin poisoning
Diphenhydramine hydrochloride and benztropine mesylate Extrapyramidal reactions associated with antipsychotic
Ethanol or fomepizole ethylene glycol poisoning and methanol poisoning
Flumazenil benzodiazepine poisoning
Glucagon beta blocker poisoning and calcium channel blocker poisoning
100% oxygen or hyperbaric oxygen therapy (HBOT) carbon monoxide poisoning and cyanide poisoning
Insulin beta blocker poisoning and calcium channel blocker poisoning
Leucovorin methotrexate and trimethoprim
Methylene blue treatment of conditions that cause methemoglobinemia
Naloxone hydrochloride opioid poisoning
N-acetylcysteine Paracetamol (acetaminophen) poisoning
Octreotide oral hypoglycemic agents
Pralidoxime chloride (2-PAM) organophosphate insecticides
Protamine sulfate Heparin poisoning
Prussian blue Thallium poisoning
Physostigmine sulfate anticholinergic poisoning
Pyridoxine Isoniazid poisoning, ethylene glycol
Phytomenadione(vitamin K) and fresh frozen plasma warfarin poisoning and indanedione
Sodium bicarbonate ASA, TCAs with a wide QRS


See also

Simple English

An antidote is a substance or a thing that can make people feel better who took a certain poison. The antidote will make some of the effects of the poison go away.

Antidotes are specific to certain poisons. They often are poisons themselves. As an example, Atropine, a substance that is found in the deadly nightshade is a very poisonous substance. However, by the way it reacts with the body, it is used as an antidote against some insecticides, as well as certain kinds of nerve gas.

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