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Antipyrine: Wikis

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Phenazone
Systematic (IUPAC) name
1,2-dihydro- 1,5-dimethyl- 2-phenyl- 3H-pyrazol- 3-one
Identifiers
CAS number 60-80-0
ATC code N02BB01 S02DA03
PubChem 2206
DrugBank DB01435
ChemSpider 2121
Chemical data
Formula C 11H12N2O 
Mol. mass 188.226 g/mol
SMILES eMolecules & PubChem
Synonyms analgesine, antipyrine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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Phenazone (INN), phenazon, antipyrine (USAN), or analgesine is an analgesic and antipyretic. It was first synthesized by Ludwig Knorr in 1883.[1] It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.

Adverse effects

Possible adverse effects include:

See also

References

  1. ^ Brune, K (1997). "The early history of non-opioid analgesics". Acute Pain 1: 33. doi:10.1016/S1366-0071(97)80033-2.  
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1911 encyclopedia

Up to date as of January 14, 2010
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From LoveToKnow 1911

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