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Antrafenine: Wikis

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Antrafenine
Systematic (IUPAC) name
2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl 2-[(7-(trifluoromethyl)quinolin-4-yl)amino]benzoate
Identifiers
CAS number 55300-30-6
ATC code none
PubChem 68723
DrugBank DB01419
Chemical data
Formula C 30H26F6N4O2  
Mol. mass 588.543 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life  ?
Excretion renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes oral

Antrafenine (Stakane) is a piperazine derivative drug invented in 1979.[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs.

References

  1. ^ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
  2. ^ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.
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