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Apoptosis antagonizing transcription factor
Symbols AATF; CHE1; CHE-1; DED
External IDs OMIM608463 MGI1929608 HomoloGene40811 GeneCards: AATF Gene
Species Human Mouse
Entrez 26574 56321
Ensembl ENSG00000108270 ENSMUSG00000018697
UniProt Q9NY61 Q3URN5
RefSeq (mRNA) NM_012138 XM_988395
RefSeq (protein) NP_036270 XP_993489
Location (UCSC) Chr 17:
32.38 - 32.49 Mb
Chr 11:
84.24 - 84.33 Mb
PubMed search [1] [2]

Protein AATF is a protein that in humans is encoded by the AATF gene.[1][2][3]

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[3]



Apoptosis antagonizing transcription factor has been shown to interact with Sp1 transcription factor,[4] POLR2J,[2] PAWR[5] and Retinoblastoma protein.[6][2]


  1. ^ Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Maki M, Kainulainen H (Oct 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochem Biophys Res Commun 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528.  
  2. ^ a b c Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (Jun 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J 14 (7): 904–12. PMID 10783144.  
  3. ^ a b "Entrez Gene: AATF apoptosis antagonizing transcription factor".  
  4. ^ Di Padova, Monica; Bruno Tiziana, De Nicola Francesca, Iezzi Simona, D'Angelo Carmen, Gallo Rita, Nicosia Daniela, Corbi Nicoletta, Biroccio Annamaria, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio (Sep. 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". J. Biol. Chem. (United States) 278 (38): 36496–504. doi:10.1074/jbc.M306694200. ISSN 0021-9258. PMID 12847090.  
  5. ^ Guo, Qing; Xie Jun (Feb. 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". J. Biol. Chem. (United States) 279 (6): 4596–603. doi:10.1074/jbc.M309811200. ISSN 0021-9258. PMID 14627703.  
  6. ^ Bruno, Tiziana; De Angelis Roberta, De Nicola Francesca, Barbato Christian, Di Padova Monica, Corbi Nicoletta, Libri Valentina, Benassi Barbara, Mattei Elisabetta, Chersi Alberto, Soddu Silvia, Floridi Aristide, Passananti Claudio, Fanciulli Maurizio (Nov. 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell (United States) 2 (5): 387–99. ISSN 1535-6108. PMID 12450794.  

Further reading

  • Page G, Lödige I, Kögel D, Scheidtmann KH (2000). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.". FEBS Lett. 462 (1-2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117.  
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.  
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.  
  • Bruno T, De Angelis R, De Nicola F, et al. (2003). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.". Cancer Cell 2 (5): 387–99. doi:10.1016/S1535-6108(02)00182-4. PMID 12450794.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Di Padova M, Bruno T, De Nicola F, et al. (2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.". J. Biol. Chem. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.  
  • Guo Q, Xie J (2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.". J. Biol. Chem. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.  
  • Barbato C, Corbi N, Canu N, et al. (2004). "Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.". Mol. Cell. Neurosci. 24 (4): 1038–50. doi:10.1016/j.mcn.2003.08.002. PMID 14697667.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Burgdorf S, Leister P, Scheidtmann KH (2004). "TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination.". J. Biol. Chem. 279 (17): 17524–34. doi:10.1074/jbc.M313703200. PMID 14761944.  
  • Xie J, Guo Q (2004). "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide.". Neurobiol. Dis. 16 (1): 150–7. doi:10.1016/j.nbd.2004.02.003. PMID 15207272.  
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.  
  • Kaul D, Mehrotra A (2007). "Functional characterization of AATF transcriptome in human leukemic cells.". Mol. Cell. Biochem. 297 (1-2): 215–20. doi:10.1007/s11010-006-9317-1. PMID 17006618.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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