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Updated live from Wikipedia, last check: June 19, 2013 07:07 UTC (52 seconds ago)

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Aprindine
Systematic (IUPAC) name
{3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine
Identifiers
CAS number 37640-71-4
ATC code C01BB04
PubChem 2218
ChemSpider 2132
Chemical data
Formula C 22H30N2  
Mol. mass 322.487 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Aprindine is a Class 1b antiarrhythmic agent.[1]

In one study, it delayed atrial fibrillation more than digoxin did.[2]

It has shown effectiveness when given orally.[3]

References

  1. ^ Sato R, Hisatome I, Tanaka Y, et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. PMID 1660104.  
  2. ^ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation". Circ. J. 66 (6): 553–6. PMID 12074271. http://joi.jlc.jst.go.jp/JST.JSTAGE/circj/66.553?from=PubMed.  
  3. ^ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J 39 (12): 1353–60. PMID 603737. PMC 483421. http://heart.bmj.com/cgi/pmidlookup?view=long&pmid=603737.  
Antiarrhythmic agents (C01B)
Channel blockers
class Ia (Phase 0→ and Phase 3→)
class Ib (Phase 3←)
IV (Lidocaine #) • enteral (Mexiletine, Tocainide, Aprindine)
class Ic (Phase 0→)
Receptor agonists
and antagonists
Propranolol • Nadolol • Pindolol • cardioselective (Atenolol, Metoprolol, Acebutolol, Esmolol)
Ion transporters
# = WHO-EM







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