The Full Wiki

More info on Aquaporin 3

Aquaporin 3: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

aquaporin 3 (Gill blood group)
Symbols AQP3; GIL
External IDs OMIM600170 MGI1333777 HomoloGene21025 GeneCards: AQP3 Gene
Species Human Mouse
Entrez 360 11828
Ensembl ENSG00000165272 ENSMUSG00000028435
UniProt Q92482 Q8R2N1
RefSeq (mRNA) NM_004925 NM_016689
RefSeq (protein) NP_004916 NP_057898
Location (UCSC) Chr 9:
33.43 - 33.44 Mb
Chr 4:
41.04 - 41.05 Mb
PubMed search [1] [2]

Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.[1] In kidney, AQP3 gene expression is not regulated by vasopressin (ADH).[2] This protein is also a determinant for the GIL blood group system.[3]


See also


  1. ^ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461.  
  2. ^ Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. PMID 9824541.  
  3. ^ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222.  

Further reading

  • Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte.". Mol. Biochem. Parasitol. 167 (1): 48-53. doi:10.1016/j.molbiopara.2009.04.006. PMID 19393693.  
  • Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations.". Transfusion 48 (6): 1164-8. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676.  
  • Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture.". J. Soc. Gynecol. Investig. 13 (3): 181-5. doi:10.1016/j.jsgi.2006.02.002. PMID 16638588.  
  • Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells.". Respiratory physiology & neurobiology 161 (2): 111-8. doi:10.1016/j.resp.2007.12.007. PMID 18280225.  
  • Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine.". Biochem. Biophys. Res. Commun. 373 (4): 613-7. doi:10.1016/j.bbrc.2008.06.086. PMID 18601899.  
  • Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.". Biochem. Biophys. Res. Commun. 387 (3): 564-8. doi:10.1016/j.bbrc.2009.07.077. PMID 19619514.  
  • Olsson M, Broberg A, JernÃ¥s M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema.". Allergy 61 (9): 1132-7. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518.  
  • Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin.". J. Invest. Dermatol. 128 (3): 542-8. doi:10.1038/sj.jid.5701047. PMID 17943189.  
  • Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine.". Int J Environ Res Public Health 5 (2): 115-9. PMID 18678926.  
  • Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line.". J. Biol. Chem. 281 (27): 18401-7. doi:10.1074/jbc.M601266200. PMID 16672223.  
  • Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing.". J. Mol. Med. 86 (2): 221-31. doi:10.1007/s00109-007-0272-4. PMID 17968524.  
  • Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis.". Arch. Dermatol. Res. 301 (3): 245-52. doi:10.1007/s00403-009-0927-9. PMID 19184071.  
  • Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate.". Int. J. Urol. 14 (12): 1088-92; discussion 1092. doi:10.1111/j.1442-2042.2007.01901.x. PMID 18036046.  
  • Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin.". J. Cell. Biochem. 102 (4): 1051-8. doi:10.1002/jcb.21350. PMID 17471492.  
  • Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation.". J. Cell. Physiol. 217 (2): 338-49. doi:10.1002/jcp.21506. PMID 18543247.  
  • Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc.". J. Mol. Histol. 39 (3): 303-9. doi:10.1007/s10735-008-9166-1. PMID 18247144.  
  • Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells.". Stem Cells 23 (7): 992-1001. doi:10.1634/stemcells.2004-0197. PMID 16043462.  
  • Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.". J. Membr. Biol. 208 (1): 55-64. doi:10.1007/s00232-005-0819-7. PMID 16596446.  
  • Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues.". Hum. Pathol. 38 (1): 171-8. doi:10.1016/j.humpath.2006.07.015. PMID 17056099.  

External links



Got something to say? Make a comment.
Your name
Your email address