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From Wikipedia, the free encyclopedia

An aquaretic is a class of drug that is used to promote aquaresis. They are not strictly speaking diuretics, but are sometimes classified as such.

Contents

Species

Herbal aquaretics include adonis, agrimony, bearberry, buchu, dandelion, heartsease, hydrangea, lady's mantle, larch, and sassafras.

Pharmacokinetics

These increase blood flow to the kidneys without increasing sodium and chloride resorption, thus causing an increase in urine whilst retaining electrolytes. However, the increase in intravascular fluid volume that they cause translates into an increase vascular resistance, and higher blood pressure.[1]

Chemical constitutents

Synthetic aquaretics, a new class of drug, are V2 receptor antagonists, such as OPC-31260. Additional examples include conivaptan, demeclocycline, and lithium. These have been used in clinical trials as a treatment for Syndrome of inappropriate antidiuretic hormone (SIADH).[2][3]

References

  1. ^ Lucinda G. Miller and Wallace J. Murray (1998). Herbal Medicinals: A Clinician's Guide. Haworth Press. pp. 147. ISBN 0789004666.  
  2. ^ Toshikazu Saito, San-e Ishikawa, Keishi Abe, Kyuzi Kamoi, Kenichi Yamada, Kurakazu Shimizu, Takao Saruta and Sho Yoshida (April 1997). "Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)". The Journal of Clinical Endocrinology & Metabolism (The Endocrine Society) 82 (4): 1054–1057. PMID 9100572.  
  3. ^ D. A. Warrell, Timothy M. Cox, and John D. Firth (2003). Oxford Textbook of Medicine. Oxford University Press. pp. 211–212. ISBN 0198569785.  

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