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The ML-4400 is a modular unit and supports various plugins boards to support up to 320 channels of input.
The ML-4400 requires adapter pods as well as the plugin boards to function.
The ML-4100 is a fixed unit which supported various logic analyzer modes, as well as pods for monitoring various CPUs for debug purposes.
The ML-4100 has a 60 pin bus which allows connection of pods.
This bus is not compatible with the ML-4400, unless a special adapter is used.