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Armodafinil: Wikis


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Systematic (IUPAC) name
CAS number 112111-43-0
ATC code N06BA07
PubChem 9690109
ChemSpider 7962943
Chemical data
Formula C 15H15NO2S 
Mol. mass 273.351
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic, including CYP3A4 and other pathways
Half life 12-15 hrs
Excretion Urine (as metabolites)
Therapeutic considerations
Pregnancy cat. C
Legal status Schedule IV (US) Prescription only
Routes Oral

Armodafinil (Nuvigil) is a stimulant-like drug produced by the pharmaceutical company Cephalon Inc., which was approved by the FDA on June 15, 2007. [1] Armodafinil is the active (−)-(R)-enantiomer of the racemic drug modafinil (Provigil).

Cephalon plans to conduct clinical trials evaluating the use of Nuvigil as a treatment for serious medical conditions such as bipolar depression, cognition abnormalities associated with schizophrenia, and excessive sleepiness, and fatigue in conditions such as Parkinson's disease, cancer,[2 ] and narcolepsy, which is a sleep disorder. Nuvigil is protected by a U.S. patent expiring in 2023 that claims the Form 1 polymorph of armodafinil.

Nuvigil is available for prescription as of June 1, 2009. As of January 6th, 2010, it is being considered for the first FDA-approved medicinally-specific drug for combating jet-lag

See also


  1. ^ "CDER Drug and Biologic Approvals for Calendar Year 2007". Retrieved 2008-01-21.  
  2. ^ "Cephalon - Pipeline,". Retrieved 2008-01-21.  

External links

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