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Atrasentan
Systematic (IUPAC) name
(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
Identifiers
CAS number  ?
ATC code none
PubChem 159594
Chemical data
Formula C 29H38N2O6  
Mol. mass 510.621 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer[1], including non-small cell lung cancer.[2]

It is an endothelin receptor antagonist selective for subtype A (ETA). While other drugs of this type (sitaxentan, ambrisentan) exploit the vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation.

References

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