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Atrial natriuretic peptide receptor: Wikis

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A atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.[1]

Contents

Mechanism

NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein linked and furthermore is a "clearance receptor" which acts to internalise and destroy the ligand.

ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG) which will then induce smooth muscle relaxation. This is particularly important in the vasculature where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause them to relax. This relaxation will decrease total peripheral resistance which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart having to do less work.

There is also a soluble guanylyl cyclase which CANNOT be stimulated by ANP. Instead, vascular endothelial cells with use L-arginine to make nitrous oxide via nitrous oxide synthase. The nitrous oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP will cause vasodilation with the same effects as described above. This is why nitroglycerine is given to a person who is having a heart attack. The nitroglycerine will be metabolized to nitrous oxide which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries which will help the ischemic cardiac myocytes.

Types

There are three distinct atrial natriuretic factor receptors identified so far in mammals, natriuretic peptide receptors 1, 2 and 3.

natriuretic peptide receptor A/ guanylate cyclase A (atrionatriuretic peptide receptor A)
Identifiers
Symbol NPR1
Alt. symbols ANPRA, NPRA
Entrez 4881
HUGO 7943
OMIM 108960
RefSeq NM_000906
UniProt P16066
Other data
Locus Chr. 1 q21-q22
natriuretic peptide receptor B/ guanylate cyclase B (atrionatriuretic peptide receptor B)
Identifiers
Symbol NPR2
Alt. symbols ANPRB, NPRB
Entrez 4882
HUGO 7944
OMIM 108961
RefSeq NM_003995
UniProt P20594
Other data
Locus Chr. 9 p21-p12
natriuretic peptide receptor C/ guanylate cyclase C (atrionatriuretic peptide receptor C)
Identifiers
Symbol NPR3
Alt. symbols NPRC, ANPRC
Entrez 4883
HUGO 7945
OMIM 108962
RefSeq NM_000908
UniProt P17342
Other data
Locus Chr. 5 p14-p1


References

  1. ^ Hirose S, Hagiwara H, Takei Y (August 2001). "Comparative molecular biology of natriuretic peptide receptors". Can. J. Physiol. Pharmacol. 79 (8): 665–72. PMID 11558675.  

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