The Full Wiki

Autoimmune hepatitis: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Autoimmune hepatitis
Classification and external resources
ICD-10 K75.4
ICD-9 571.42
DiseasesDB 1150
MedlinePlus 000245
eMedicine med/366
MeSH D019693

Anomalous presentation of human leukocyte antigen (HLA) class II on the surface of hepatocytes, possibly due to genetic predisposition or acute liver infection; causes a cell-mediated immune response against the body's own liver, resulting in autoimmune hepatitis.

Autoimmune hepatitis has an incidence of 1-2 per 100,000 per year, and a prevalence of 10-20/100,000. As with most other autoimmune diseases, it affects women much more often than men (70%).[1] Liver enzymes are elevated, as may be bilirubin. Autoimmune hepatitis can progress to cirrhosis.



Four subtypes are recognised, but the clinical utility of distinguishing subtypes is limited.

  1. positive ANA and SMA,[2] raised immunoglobulin G (classic form, responds well to low dose steroids);
  2. positive LKM-1 (typically female children and teenagers; disease can be severe);
  3. positive antibodies against soluble liver antigen[3] (this group behaves like group 1)[4 ]
  4. no autoantibodies detected (~20%)


The diagnosis of autoimmune hepatitis is best achieved with a combination of clinical, laboratory and histological findings.

A number of specific antibodies found in the blood (antinuclear antibody (ANA), anti-Smooth Muscle Antibody (SMA), liver/kidney microsomal antibody (LKM-1), anti soluble liver antigen (SLA/LP) and anti-mitochondrial antibody (AMA)) are of use, as is finding an increased Immunoglobulin G level. However, the diagnosis of autoimmune hepatitis always requires a liver biopsy.

In complex cases, a scoring system can be used to help determine if a patient has autoimmune hepatitis, which combines clinical and laboratory features of a given case.[5][6 ]

Overlapping presentation with primary biliary cirrhosis and primary sclerosing cholangitis has been observed.[7]


Treatment is with glucocorticoids with or without azathioprine and remission can be achieved in up to 60–80% of cases, although many will eventually experience a relapse.[8]. Patients who donot respond to glucocorticoids and azathioprine may be given other immunosuppressives like cyclosporin, tacrolimus, methotrexate etc. Liver transplantation may be required if patients do not respond to drug therapy or when patients present with fulminant liver failure.[9]


  1. ^ "Autoimmune Hepatitis".  
  2. ^ Bogdanos DP, Invernizzi P, Mackay IR, Vergani D (June 2008). "Autoimmune liver serology: Current diagnostic and clinical challenges". World J. Gastroenterol. 14 (21): 3374–3387. doi:10.3748/wjg.14.3374. PMID 18528935.  
  3. ^ "autoimmune hepatitis".  
  4. ^ "Medscape & eMedicine Log In".  
  5. ^ Alvarez F, Berg PA, Bianchi FB, et al. (November 1999). "International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis". J. Hepatol. 31 (5): 929–38. doi:10.1016/S0168-8278(99)80297-9. PMID 10580593. Retrieved 2008-05-09.  
  6. ^ "Autoimmune Hepatitis Calculator". Retrieved 2008-05-09.  
  7. ^ Washington MK (February 2007). "Autoimmune liver disease: overlap and outliers". Mod. Pathol. 20 Suppl 1: S15–30. doi:10.1038/modpathol.3800684. PMID 17486048.  
  8. ^ Krawitt EL (January 1994). "Autoimmune hepatitis: classification, heterogeneity, and treatment". Am. J. Med. 96 (1A): 23S–26S. doi:10.1016/0002-9343(94)90186-4. PMID 8109584.  
  9. ^ Stephen J Mcphee, Maxine A Papadakis. Current medical diagnosis and treatment 2009 page.596


Got something to say? Make a comment.
Your name
Your email address