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Autoimmune lymphoproliferative syndrome
Classification and external resources
OMIM 601859 603909
DiseasesDB 33425 33424

Autoimmune lymphoproliferative syndrome is a form of lymphoproliferative disorder. It affects lymphocyte apoptosis.[1]

ALPS results from mutations in the human genes, Fas and FasL, which are upstream effectors of the apoptotic pathway in cells.


Among the possible symptoms are splenomegaly and hepatomegaly. [2]


Types include:


  1. ^ Fleisher TA (2008). "The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis". Immunol. Res. 40 (1): 87–92. doi:10.1007/s12026-007-8001-1. PMID 18193364.  
  2. ^ "Autoimmune Lymphoproliferative Syndrome (ALPS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)". Retrieved 2008-03-01.  
  3. ^ synd/2128 at Who Named It?
  4. ^ Canale VC, Smith CH (June 1967). "Chronic lymphadenopathy simulating malignant lymphoma". J. Pediatr. 70 (6): 891–9. doi:10.1016/S0022-3476(67)80262-2. PMID 4165068.  
  5. ^ "Autoimmune Lymphoproliferative Syndrome". Retrieved 2008-03-01.  


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