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Autoimmune polyendocrine syndrome type 2
Classification and external resources
ICD-10 E31.0
ICD-9 258.1
OMIM 269200
DiseasesDB 29690
eMedicine med/1868
MeSH D016884

Autoimmune polyendocrine syndrome type 2 is a form of autoimmune polyendocrine syndrome.

Autoimmune polyendocrine syndrome, type 2 (also known as "Schmidt's syndrome"[1], or APS-II) is the most common form of the polyglandular failure syndromes.[2] It is more heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular HLA genotype (DQ2, DQ8 and DRB1*0404). APS-II affects women to a greater degree than men (75% of cases occur in women).[2]

Features of this syndrome are:

Symptoms Addison's Disease and Hashimoto's Thyroiditis Type 2

  • Dry hair
  • Nausea
  • Abdominal Pain
  • Frequent Urination
  • Overheating
  • Vomiting
  • Weight and Muscle Loss
  • Salt Cravings
  • Anorexia and chachexia
  • High Pulse/Weakened Heart
  • Low Blood Pressure
  • Weakness
  • Hypoglycemia
  • Numbness in Extremities
  • Migraines
  • Poor Immune System Response - Lacking Natural Bodily Inflammatories

Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3[4] and 4), but research evidence for these distinct combinations is not convincing.


  1. ^ Heuss D, Engelhardt A, Göbel H, Neundörfer B (June 1995). "Myopathological findings in interstitial myositis in type II polyendocrine autoimmune syndrome (Schmidt's syndrome)". Neurol. Res. 17 (3): 233–7. PMID 7643982.  
  2. ^ a b Greenspan, Francis S.; Gardner, David C. (2004). Basic clinical endocrinology. New York: McGraw-Hill. pp. 103. ISBN 0-07-140297-7.  
  3. ^ Betterle C, Zanchetta R (April 2003). "Update on autoimmune polyendocrine syndromes (APS)". Acta Biomed 74 (1): 9–33. PMID 12817789.  
  4. ^ de Carmo Silva R, Kater CE, Dib SA, et al (February 2000). "Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III". Eur. J. Endocrinol. 142 (2): 187–94. PMID 10664529. Retrieved 2008-07-25.  


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