The Full Wiki

More info on Autoimmune polyendocrine syndrome type 2

Autoimmune polyendocrine syndrome type 2: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Autoimmune polyendocrine syndrome type 2
Classification and external resources
ICD-10 E31.0
ICD-9 258.1
OMIM 269200
DiseasesDB 29690
eMedicine med/1868
MeSH D016884

Autoimmune polyendocrine syndrome type 2 is a form of autoimmune polyendocrine syndrome.

Autoimmune polyendocrine syndrome, type 2 (also known as "Schmidt's syndrome"[1], or APS-II) is the most common form of the polyglandular failure syndromes.[2] It is more heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular HLA genotype (DQ2, DQ8 and DRB1*0404). APS-II affects women to a greater degree than men (75% of cases occur in women).[2]

Features of this syndrome are:

Symptoms Addison's Disease and Hashimoto's Thyroiditis Type 2

  • Dry hair
  • Nausea
  • Abdominal Pain
  • Frequent Urination
  • Overheating
  • Vomiting
  • Weight and Muscle Loss
  • Salt Cravings
  • Anorexia and chachexia
  • High Pulse/Weakened Heart
  • Low Blood Pressure
  • Weakness
  • Hypoglycemia
  • Numbness in Extremities
  • Migraines
  • Poor Immune System Response - Lacking Natural Bodily Inflammatories

Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3[4] and 4), but research evidence for these distinct combinations is not convincing.

References

  1. ^ Heuss D, Engelhardt A, Göbel H, Neundörfer B (June 1995). "Myopathological findings in interstitial myositis in type II polyendocrine autoimmune syndrome (Schmidt's syndrome)". Neurol. Res. 17 (3): 233–7. PMID 7643982.  
  2. ^ a b Greenspan, Francis S.; Gardner, David C. (2004). Basic clinical endocrinology. New York: McGraw-Hill. pp. 103. ISBN 0-07-140297-7.  
  3. ^ Betterle C, Zanchetta R (April 2003). "Update on autoimmune polyendocrine syndromes (APS)". Acta Biomed 74 (1): 9–33. PMID 12817789.  
  4. ^ de Carmo Silva R, Kater CE, Dib SA, et al (February 2000). "Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III". Eur. J. Endocrinol. 142 (2): 187–94. PMID 10664529. http://eje-online.org/cgi/pmidlookup?view=long&pmid=10664529. Retrieved 2008-07-25.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message