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Systematic (IUPAC) name

[2-(hydroxymethyl)-1-pyrrolidinyl]-N- (2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

CAS number 330784-47-9
ATC code none
PubChem 9869929
ChemSpider 8045620
Chemical data
Formula C 23H26ClN7O3  
Mol. mass 483.951 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Avanafil (dubbed as "Son of Viagra"[1]) is a PDE5 inhibitor being developed for erectile dysfunction. Avanafil currently has no trademarked term associated with it but it being developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase type 5 enzyme which if found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil.


See also


Further reading

External links

Avanafil News and Forum

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