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Avanafil
Systematic (IUPAC) name
4-[(3-Chloro-4-methoxybenzyl)amino]-2-

[2-(hydroxymethyl)-1-pyrrolidinyl]-N- (2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

Identifiers
CAS number 330784-47-9
ATC code none
PubChem 9869929
ChemSpider 8045620
Chemical data
Formula C 23H26ClN7O3  
Mol. mass 483.951 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Avanafil (dubbed as "Son of Viagra"[1]) is a PDE5 inhibitor being developed for erectile dysfunction. Avanafil currently has no trademarked term associated with it but it being developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase type 5 enzyme which if found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil.

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External links

Avanafil News and Forum








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